en Educational Psychology پژوهشي Original <div style="text-align: justify;"><span style="color:#669933;"><span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:2;"><b>Objective:</b> Patients with hematologic malignancies, particularly during aggressive treatments such as hematopoietic stem cell transplantation, face extensive physical, psychological, and social challenges that significantly affect their quality of life. The present study aimed to explore the lived experiences of these patients, with an emphasis on the role of cognitive flexibility in improving quality of life.<span dir="RTL" lang="AR-SA"><span style="font-family:"Arial",sans-serif"></span></span><br> <b>Methods</b>: This study was conducted using a qualitative approach and an interpretative phenomenological methodology. Participants included patients with hematologic malignancies who were hospitalized in the hematopoietic stem cell transplantation unit. Data were collected through semi-structured interviews and analyzed using thematic analysis.<span dir="RTL" lang="AR-SA"><span style="font-family:"Arial",sans-serif"></span></span><br> <b>Results</b>: Data analysis led to the identification of several core themes highlighting the central role of cognitive flexibility in patients&rsquo; quality of life experiences. These themes included redefining the meaning of illness, acceptance of reality accompanied by hope, modification of maladaptive cognitive patterns, and active adaptation to treatment-related limitations. Cognitively flexible patients demonstrated a greater ability to regulate emotions, reduce perceived stress, and maintain a sense of meaning and purpose in life.<span dir="RTL" lang="AR-SA"><span style="font-family:"Arial",sans-serif"></span></span><br> <b>Conclusions</b>: Cognitive flexibility, as a key psychological resource, plays a significant role in improving the quality of life of patients with hematologic malignancies. Designing supportive and psychological interventions focused on enhancing cognitive flexibility may contribute substantially to improving the quality of life of these patients.</span></span></span></span></div> Hematologic malignancies, Quality of life, Cognitive flexibility, Lived experience, Qualitative study 0 0 http://ijer.hormozgan.ac.ir/browse.php?a_code=A-10-550-1&slc_lang=en&sid=1 Fatemeh Haji Fathali Fathalif@iau.ac.ir 10031947532846004907 10031947532846004907 No Department of Psychology, C.T.C., Islamic Azad University, Tehran, Iran Susan Emamipour Susan.Emamipoor@iau.ac.ir 10031947532846004908 10031947532846004908 Yes Department of Psychology, C.T.C., Islamic Azad University, Tehran, Iran Lida Leilabadie Leilabadiel@iau.ac.ir 10031947532846004909 10031947532846004909 No Department of Psychology, C.T.C., Islamic Azad University, Tehran, Iran Marjan Alizadeh Alizadehm@iau.ac.ir 10031947532846004910 10031947532846004910 No Department of Psychology, C.T.C., Islamic Azad University, Tehran, Iran